BDBM259808 US9505766, 74::US9505766, CN-NHiPr (7)

SMILES CC(C)NC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N

InChI Key InChIKey=POTINGKLYOETSI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259808   

TargetRibosomal protein S6 kinase alpha-3 [399-740](Human)
University of California

US Patent
LigandPNGBDBM259808(US9505766, CN-NHiPr (7) | US9505766, 74)
Affinity DataIC50: 5nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase alpha-3 [399-740,C436V](Human)
University of California

US Patent
LigandPNGBDBM259808(US9505766, CN-NHiPr (7) | US9505766, 74)
Affinity DataIC50: 5.50E+3nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase alpha-3 [399-740](Human)
University of California

US Patent
LigandPNGBDBM259808(US9505766, CN-NHiPr (7) | US9505766, 74)
Affinity DataIC50: 500nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM259808(US9505766, CN-NHiPr (7) | US9505766, 74)
Affinity DataIC50: 5nMAssay Description:Inhibition of RSK2 in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed