BDBM259803 US9505766, acrylonitrile (3)

SMILES Cc1ccc(cc1)-c1c(\C=C\C#N)n(CCCO)c2ncnc(N)c12

InChI Key InChIKey=LPADWFDQODOOMS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 259803   

TargetRibosomal protein S6 kinase alpha-3 [399-740](Human)
University of California

US Patent
LigandPNGBDBM259803(US9505766, acrylonitrile (3))
Affinity DataIC50: 750nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase alpha-3 [399-740,C436V](Human)
University of California

US Patent
LigandPNGBDBM259803(US9505766, acrylonitrile (3))
Affinity DataIC50: 1.50E+3nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM259803(US9505766, acrylonitrile (3))
Affinity DataIC50: 750nMAssay Description:Inhibition of RSK2 in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2019
Entry Details Article
PubMed