BDBM25957 4-[3-(aminomethyl)phenyl]-N,12-dimethyl-3-thia-1,7,10-triazatricyclo[7.3.0.0^{2,6}]dodeca-2(6),4,7,9,11-pentaen-8-amine::imidazothienopyrazine, 22a

SMILES CNc1nc2cc(sc2n2c(C)cnc12)-c1cccc(CN)c1

InChI Key InChIKey=ZAUQKMTUOLGTHT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 25957   

LigandPNGBDBM25957(4-[3-(aminomethyl)phenyl]-N,12-dimethyl-3-thia-1,7...)
Affinity DataIC50: 220nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2008
Entry Details Article
PubMed
LigandPNGBDBM25957(4-[3-(aminomethyl)phenyl]-N,12-dimethyl-3-thia-1,7...)
Affinity DataIC50: 8.5nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2008
Entry Details Article
PubMed
LigandPNGBDBM25957(4-[3-(aminomethyl)phenyl]-N,12-dimethyl-3-thia-1,7...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human IKK-beta using TMB as substrate after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM25957(4-[3-(aminomethyl)phenyl]-N,12-dimethyl-3-thia-1,7...)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human IKKbeta using GST-IkappaBalpha as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed