BDBM259545 US9505749, 56

SMILES O=C(CCCc1nc2ccccc2c(=O)[nH]1)N[C@H]1CC[C@@H](CC1)Oc1ccccn1

InChI Key InChIKey=PHWWAZGJHKJDLI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259545   

LigandPNGBDBM259545(US9505749, 56)
Affinity DataIC50: 2.51nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
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LigandPNGBDBM259545(US9505749, 56)
Affinity DataIC50: 0.719nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
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TargetPoly [ADP-ribose] polymerase 1(Human)
Amgen

US Patent
LigandPNGBDBM259545(US9505749, 56)
Affinity DataIC50: 5.82E+3nMAssay Description:PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Amgen

US Patent
LigandPNGBDBM259545(US9505749, 56)
Affinity DataIC50: 1.10E+3nMAssay Description:PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent