BDBM259544 US9505749, 55

SMILES O=C(CCCc1nc2ccccc2c(=O)[nH]1)N1CCN(CC1)c1n[nH]c2ccccc12

InChI Key InChIKey=ABCZORPRBCURRK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259544   

LigandPNGBDBM259544(US9505749, 55)
Affinity DataIC50: 1.76nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

LigandPNGBDBM259544(US9505749, 55)
Affinity DataIC50: 0.401nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Amgen

US Patent
LigandPNGBDBM259544(US9505749, 55)
Affinity DataIC50: 1.80E+3nMAssay Description:PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Amgen

US Patent
LigandPNGBDBM259544(US9505749, 55)
Affinity DataIC50: 284nMAssay Description:PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent