BDBM259540 US9505749, 51

SMILES Fc1ccc2n(C3CCN(CC3)C(=O)CCCc3nc4ccccc4c(=O)[nH]3)c(=O)[nH]c2c1

InChI Key InChIKey=CKOUULRCBKAWEI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259540   

LigandPNGBDBM259540(US9505749, 51)
Affinity DataIC50: 4.09nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
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LigandPNGBDBM259540(US9505749, 51)
Affinity DataIC50: 0.517nMAssay Description:The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
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TargetPoly [ADP-ribose] polymerase 1(Human)
Amgen

US Patent
LigandPNGBDBM259540(US9505749, 51)
Affinity DataIC50: 894nMAssay Description:PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
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TargetPoly [ADP-ribose] polymerase 2(Human)
Amgen

US Patent
LigandPNGBDBM259540(US9505749, 51)
Affinity DataIC50: 553nMAssay Description:PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
Go to US Patent