BDBM259450 US9512114, 9::US9657007, Example 9

SMILES C[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=HJAUKGHNPOFPSW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 259450   

LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50: 2.68E+3nMT: 2°CAssay Description:PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50: 226nMT: 2°CAssay Description:PI3K (p1103/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as requ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50: 4nMT: 2°CAssay Description:PI3K (p110δ/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50: 255nMT: 2°CAssay Description:PI3K (p120γ) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as required)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Calitor Sciences

US Patent
LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50: 2.68E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50: 226nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50: 4nMAssay Description:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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LigandPNGBDBM259450(US9512114, 9 | US9657007, Example 9)
Affinity DataIC50: 255nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent