BDBM259449 US9512114, 8::US9657007, Example 8

SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=VOHXNNFKUJLLLQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 259449   

LigandPNGBDBM259449(US9512114, 8 | US9657007, Example 8)
Affinity DataIC50: 276nMT: 2°CAssay Description:PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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LigandPNGBDBM259449(US9512114, 8 | US9657007, Example 8)
Affinity DataIC50: 33nMT: 2°CAssay Description:PI3K (p1103/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as requ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

LigandPNGBDBM259449(US9512114, 8 | US9657007, Example 8)
Affinity DataIC50: 1nMT: 2°CAssay Description:PI3K (p110δ/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

LigandPNGBDBM259449(US9512114, 8 | US9657007, Example 8)
Affinity DataIC50: 74nMT: 2°CAssay Description:PI3K (p120γ) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as required)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Calitor Sciences

US Patent
LigandPNGBDBM259449(US9512114, 8 | US9657007, Example 8)
Affinity DataIC50: 276nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

LigandPNGBDBM259449(US9512114, 8 | US9657007, Example 8)
Affinity DataIC50: 33nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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LigandPNGBDBM259449(US9512114, 8 | US9657007, Example 8)
Affinity DataIC50: 1nMAssay Description:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white 384 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
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LigandPNGBDBM259449(US9512114, 8 | US9657007, Example 8)
Affinity DataIC50: 74nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent