BDBM259332 US9505745, 9::US9790212, Example 9

SMILES Cc1c(cnn1-c1ccccc1)C(=O)NCc1c(C)cc(C)[nH]c1=O

InChI Key InChIKey=LLWAEAQGDHLXKV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 259332   

LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)
Affinity DataIC50: 2.00E+4nMAssay Description:Protocol 1: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)
Affinity DataIC50: 6.31E+4nMAssay Description:Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)
Affinity DataIC50: 6.31E+4nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)
Affinity DataIC50: 1.54E+4nMAssay Description:Inhibition of human EZH2 using core histone as substrate incubated for 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)
Affinity DataIC50: 1.54E+4nMAssay Description:Displacement of [3H-SAM] from N-terminal His-tagged human EZH2 preincubated for 15 min followed by substrate addition measured after 1 hr by absorban...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)
Affinity DataIC50: 1.54E+4nMAssay Description:Displacement of [3H]-SAM from human EZH2 using histone substrate incubated for 1 hr by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM259332(US9505745, 9 | US9790212, Example 9)
Affinity DataIC50: 5.78E+3nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed