BDBM258866 US9499492, 18
SMILES CS(=O)(Cc1cc(Br)cc(Nc2ncc(F)c(n2)-c2ccc(F)cc2F)c1)=NC#N
InChI Key InChIKey=OBGYQQHPNRVDPR-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 258866
Affinity DataIC50: 1.00E+4nMpH: 7.4 T: 2°CAssay Description:The principle of the assay is based on the hydrolysis of 4-nitrophenyl acetate by carbonic anhydrases (Pocker & Stone, Biochemistry, 1967, 6, 668), w...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMpH: 7.4 T: 2°CAssay Description:The principle of the assay is based on the hydrolysis of 4-nitrophenyl acetate by carbonic anhydrases (Pocker & Stone, Biochemistry, 1967, 6, 668), w...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMpH: 8.0 T: 2°CAssay Description:Method 1a: Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were pu...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/Glutathione S-transferase P(Human)
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 470nMpH: 8.0 T: 2°CAssay Description:Method 2: Recombinant fusion proteins of GST and human CDK2 and of GST and human CycE, expressed in insect cells (Sf9) and purified by Glutathion-Sep...More data for this Ligand-Target Pair
Affinity DataIC50: 175nMpH: 8.0 T: 2°CAssay Description:Method 1b: Recombinant full-length His-tagged human CDK9 and CycT1, expressed in insect cells and purified by Ni-NTA affinity chromatography, were pu...More data for this Ligand-Target Pair