BDBM258595 US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-methylbenzo[c][1,2]oxaborol-1(3H)-ol::US9493490, D::US9493490, Example 4

SMILES Cc1c2B(O)OCc2ccc1Oc1ccc(CN)cc1F

InChI Key InChIKey=ZCITXZXBLWIHHP-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 258595   

TargetGlutathione S-transferase P/Rho-associated protein kinase 1 [1-535](Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258595(US9493490, Example 4 | US9493490, 6-(4-(aminomethy...)
Affinity DataIC50: 340nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetGlutathione S-transferase P/Rho-associated protein kinase 2 [5-554](Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258595(US9493490, Example 4 | US9493490, 6-(4-(aminomethy...)
Affinity DataIC50: 250nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258595(US9493490, Example 4 | US9493490, 6-(4-(aminomethy...)
Affinity DataIC50: 9.25nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetBeta-adrenergic receptor kinase 1(Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258595(US9493490, Example 4 | US9493490, 6-(4-(aminomethy...)
Affinity DataIC50: 20nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258595(US9493490, Example 4 | US9493490, 6-(4-(aminomethy...)
Affinity DataIC50: 4.06nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258595(US9493490, Example 4 | US9493490, 6-(4-(aminomethy...)
Affinity DataIC50: 20nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase alpha-1(Human)
Anacor Pharmaceuticals

US Patent
LigandPNGBDBM258595(US9493490, Example 4 | US9493490, 6-(4-(aminomethy...)
Affinity DataIC50: 5.01nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM258595(US9493490, Example 4 | US9493490, 6-(4-(aminomethy...)
Affinity DataIC50: 250nMAssay Description:Inhibition of GST-tagged ROCK1 (1 to 535 residues) (unknown origin) using S6-peptide as substrate preincubated for 15 mins followed by 33P-ATP additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM258595(US9493490, Example 4 | US9493490, 6-(4-(aminomethy...)
Affinity DataIC50: 220nMAssay Description:Inhibition of GST-tagged ROCK2 (5 to 554 residues) (unknown origin) using S6-peptide as substrate preincubated for 15 mins followed by 33P-ATP additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed