BDBM258583 US10633384, Example 12.45::US9493486, 12.45

SMILES CS(=O)(=O)c1cc(COC(=O)N2CCC3(CN(C3)S(=O)(=O)c3ccc4[nH]c(=O)oc4c3)CC2)cc(c1)C(F)(F)F

InChI Key InChIKey=SAUMRYSIRCXBFC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 258583   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM258583(US9493486, 12.45 | US10633384, Example 12.45)
Affinity DataIC50: 39nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM258583(US9493486, 12.45 | US10633384, Example 12.45)
Affinity DataIC50: 39nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2021
Entry Details
Go to US Patent