BDBM258540 US10633384, Example 12.02::US9493486, 12.02

SMILES Clc1ccc(COC(=O)N2CCC3(CN(C3)C(=O)c3ccc4[nH]nnc4c3)CC2)cc1Cl

InChI Key InChIKey=JNCFYDWBXFRFNI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 258540   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM258540(US9493486, 12.02 | US10633384, Example 12.02)
Affinity DataIC50: 44nMpH: 8.0 T: 2°CAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2017
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM258540(US9493486, 12.02 | US10633384, Example 12.02)
Affinity DataIC50: 44nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2021
Entry Details
Go to US Patent