BDBM25839 3-[5-(3-hydroxyphenyl)-1,2,4-thiadiazol-3-yl]phenol::hydroxyphenyl substituted thiadiazole, 11

SMILES Oc1cccc(c1)-c1nsc(n1)-c1cccc(O)c1

InChI Key InChIKey=OYXDKVOVGLCIIZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25839   

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Saarland University

LigandPNGBDBM25839(3-[5-(3-hydroxyphenyl)-1,2,4-thiadiazol-3-yl]pheno...)
Affinity DataIC50: 169nMpH: 7.0 T: 2°CAssay Description:Tritiated E1 was incubated with 17beta-HSD1, cofactor, and inhibitor. The amount of labeled E2 formed was quantified by HPLC. Detection and quantific...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Saarland University

LigandPNGBDBM25839(3-[5-(3-hydroxyphenyl)-1,2,4-thiadiazol-3-yl]pheno...)
Affinity DataIC50: 602nMAssay Description:Tritiated E2 was incubated with 17beta-HSD2, cofactor, and inhibitor. The amount of labeled E1 formed was quantified by HPLC. Detection and quantific...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2008
Entry Details Article
PubMed
TargetAromatase(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM25839(3-[5-(3-hydroxyphenyl)-1,2,4-thiadiazol-3-yl]pheno...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human aromatase using dibenzylfluorescein as substrate preincubated for 30 mins measured after 2 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed