BDBM258274 US9493485, 8-110

SMILES CC#Cc1cncc(c1)-c1csc(c1)[C@]1(C)CC2(CCC(F)(F)CC2)OC(N)=N1

InChI Key InChIKey=ZSHQGPMKXVXTGN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 258274   

TargetBeta-secretase 1(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258274(US9493485, 8-110)
Affinity DataIC50: 26nMpH: 7.0Assay Description:BACE1 activity can be assessed in an AlphaScreen assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially dil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258274(US9493485, 8-110)
Affinity DataIC50: 960nMpH: 4.5 T: 2°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent

TargetCathepsin D(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258274(US9493485, 8-110)
Affinity DataIC50: 5.57E+3nMpH: 4.5 T: 2°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent