BDBM258267 US9493485, 8-103

SMILES CC#Cc1cncc(c1)-c1csc(c1)C1(C)CC2(CCC2)OC(N)=N1

InChI Key InChIKey=LEMSGJHTNVBLRC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 258267   

TargetBeta-secretase 1(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258267(US9493485, 8-103)
Affinity DataIC50: 30nMpH: 7.0Assay Description:BACE1 activity can be assessed in an AlphaScreen assay. Compounds to be assessed (e.g. compounds as described in the above examples) are serially dil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258267(US9493485, 8-103)
Affinity DataIC50: 1.36E+3nMpH: 4.5 T: 2°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent

TargetCathepsin D(Human)
Imago Pharmaceuticals

US Patent
LigandPNGBDBM258267(US9493485, 8-103)
Affinity DataIC50: 7.92E+3nMpH: 4.5 T: 2°CAssay Description:Compounds are also assessed for BACE1 and Cathepsin D activity using an FP Assay. Compounds to be assessed (e.g. compounds as described in the above ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent