BDBM258112 US9493448, 14::US9493448, 31::US9597330, Example 7::US9845313, Example 31

SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1

InChI Key InChIKey=GHOSFOBBUGQTRM-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 258112   

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 150nMpH: 7.3 T: 2°CAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 58nMpH: 7.3 T: 2°CAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2017
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 150nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 58nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 150nMAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 58nMAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent

LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NaV1.1/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human NaV1.5/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel subunit beta-2(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel subunit beta-2(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed