BDBM257506 US9505736, (1R,2R,3R)-2-(4-(5- (Difluoromethoxy)pyrimidin-2-yl)phenyl)-1- fluoro-N-hydroxy-3- phenylcyclopropanecarboxamide

SMILES ONC(=O)[C@@]1(F)[C@H]([C@@H]1c1ccc(cc1)-c1ncc(OC(F)F)cn1)c1ccccc1

InChI Key InChIKey=RUTGGTYDBCHEPE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 257506   

TargetHistone deacetylase 4 [648-729,745-1057](Human)
Chdi Foundation

US Patent
LigandPNGBDBM257506(US9505736, (1R,2R,3R)-2-(4-(5- (Difluoromethoxy)py...)
Affinity DataIC50: 2.60E+4nMpH: 8.0 T: 2°CAssay Description:The potency of Class IIa Histone Deacetylase (HDAC) inhibitors is quantified by measuring the Histone Deacetylase 4 (HDAC4) catalytic domain enzymati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2017
Entry Details
Go to US Patent