BDBM25744 3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)phenyl]urea::US10383835, Compound 1555::US8501783, 1555::Urea-based compound, 25

SMILES CC(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=UAKAZEQUWPXSOS-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 25744   

TargetEpoxide hydrolase B(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Alberta

LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 3.16E+4nMpH: 7.0 T: 2°CAssay Description:Enzyme activity was measured by monitoring the appearance of fluorescent product, 6-methoxy-naphthaldehyde (ex@330 nm and em@ 465 nm) on a SpectraMax...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetEpoxide hydrolase 1(Human)
University of California

US Patent
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 11.5nMAssay Description:Inhibition assay of human soluble epoxide hydrolases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2013
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Rat)
University of California Davis

Curated by ChEMBL
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 79nMAssay Description:Inhibition of rat soluble epoxide hydrolase using [3H]-t-DPPO as a substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human soluble epoxide hydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 59nMAssay Description:Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetEpoxide hydrolase(Horse)
University of California

US Patent
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent

TargetEpoxide hydrolase(Sheep)
University of California

US Patent
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Pig)
University of California

US Patent
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 201nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent

TargetEpoxide hydrolase 1(Cat)
University of California

US Patent
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 480nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent

TargetEpoxide hydrolase 1(Dog)
University of California

US Patent
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 9.30E+3nMAssay Description:The enzyme also can be detected based on the binding of specific ligands to the catalytic site which either immobilize the enzyme or label it with a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
Go to US Patent

TargetBifunctional epoxide hydrolase 2(Mouse)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of recombinant mouse sEH using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured every 30 sec for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human sEH using CMNPC as substrate preincubated for 5 mins followed by substrate addition and measured every 30 sec for 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
University of Barcelona (Ub)

Curated by ChEMBL
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 1.15E+5nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Ar£Te Therapeutics

Curated by ChEMBL
LigandPNGBDBM25744(3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of sEH (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed