BDBM256875 US11236095, Example 11A::US9492453, 11B

SMILES CN(C)CC[C@@H](NC(=O)C1(N)CCN(CC1)c1ncnc2[nH]ccc12)c1ccc(Cl)cc1

InChI Key InChIKey=VZOXJFOAJQVTTK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 256875   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM256875(US9492453, 11B | US11236095, Example 11A)
Affinity DataIC50: 21nMpH: 7.5 T: 2°CAssay Description:This assay detects inhibitors of AKT1 (PKBα) kinase activity using Caliper LabChip LC3000. The Caliper off-chip incubation mobility shift assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2017
Entry Details
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TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM256875(US9492453, 11B | US11236095, Example 11A)
Affinity DataIC50: 2.80nMAssay Description:Following addition of compound or control to the assay plate, 6p1 peptide mix containing 3 μM substrate (5-FAM-GRPRTSSFAEG-CONH2; CRB) and 40 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent