BDBM256853 US10654855, Example 36::US11236095, Example 36::US9492453, 36

SMILES Cc1c[nH]c2ncnc(N3CCC(N)(CC3)C(=O)N[C@@H](CCO)c3ccc(Cl)cc3)c12

InChI Key InChIKey=UZDDFZFBIDVRGJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 256853   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM256853(US9492453, 36 | US10654855, Example 36 | US1123609...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:This assay detects inhibitors of AKT1 (PKBα) kinase activity using Caliper LabChip LC3000. The Caliper off-chip incubation mobility shift assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2017
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM256853(US9492453, 36 | US10654855, Example 36 | US1123609...)
Affinity DataIC50: 14nMAssay Description:For Echo dosing the solvent was 100% DMSO. A master plate was prepared with 40 ul of 10 mM stock from our Primary Liquid Store in quadrant 1 of a Lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/1/2021
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Astrazeneca

US Patent
LigandPNGBDBM256853(US9492453, 36 | US10654855, Example 36 | US1123609...)
Affinity DataIC50: 14nMAssay Description:Following addition of compound or control to the assay plate, 6p1 peptide mix containing 3 μM substrate (5-FAM-GRPRTSSFAEG-CONH2; CRB) and 40 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
Go to US Patent