BDBM256534 US10435361, Example 33::US9481648, 33::US9790174, Example 33

SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(C(=O)NC5CC5)c4OC)C(C)(C)C)c4ccccc34)n2)cc(OC)c1

InChI Key InChIKey=CGELEDQBCPRRSA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 256534   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM256534(US9481648, 33 | US9790174, Example 33 | US10435361...)
Affinity DataIC50: 11nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM256534(US9481648, 33 | US9790174, Example 33 | US10435361...)
Affinity DataIC50: 28nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM256534(US9481648, 33 | US9790174, Example 33 | US10435361...)
Affinity DataIC50: 828nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a shorter period of mixing of the test compound (105 minutes instead of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Respivert

US Patent
LigandPNGBDBM256534(US9481648, 33 | US9790174, Example 33 | US10435361...)
Affinity DataIC50: 11nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Respivert

US Patent
LigandPNGBDBM256534(US9481648, 33 | US9790174, Example 33 | US10435361...)
Affinity DataIC50: 28nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Respivert

US Patent
LigandPNGBDBM256534(US9481648, 33 | US9790174, Example 33 | US10435361...)
Affinity DataIC50: 828nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent