BDBM256339 US9487490, 1C

SMILES OC(=O)C1CCC(=CC1)c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12

InChI Key InChIKey=JAWOLYIAGCXUQG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 256339   

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM256339(US9487490, 1C)
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM256339(US9487490, 1C)
Affinity DataIC50: 107nMAssay Description:Allosteric inhibition of yeast GAL4 DNA domain-fused RORgammat LBD (97 to 518 residues) (unknown origin) expressed in HEK293T cells after 20 to 22 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM256339(US9487490, 1C)
Affinity DataIC50: 4nMAssay Description:Allosteric inhibition of recombinant His6-tagged RORgammat LBD (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as inhibition of bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed