BDBM255946 US9481672, 124

SMILES Cn1c2ccc(cc2n(C)c1=O)-n1cc(C(O)=O)c(=O)n(Cc2cccc(Cl)c2Cl)c1=O

InChI Key InChIKey=IVIOEZLOGOHCKX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 255946   

Targetchymase(Golden hamster)
Bayer

US Patent
LigandChemical structure of BindingDB Monomer ID 255946BDBM255946(US9481672, 124)
Affinity DataIC50: 7nMpH: 7.5Assay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used for ch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2017
Entry Details
US Patent

TargetChymase(Canis lupus familiaris)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 255946BDBM255946(US9481672, 124)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant dog chymase using Abz-HPFHL-Lys(Dnp)-NH2 as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetChymase(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 255946BDBM255946(US9481672, 124)
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant chymase using Abz-HPFHL-Lys(Dnp)-NH2 as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed