BDBM25589 2,6-Disubstituted Pyrazine, 52::7-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}oxy)-3,4-dihydro-2H-1-benzopyran-2-one

SMILES COc1cc(Nc2cncc(Oc3ccc4CCC(=O)Oc4c3)n2)cc(OC)c1OC

InChI Key InChIKey=WPQIHJNEPXGQCO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25589   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Cancer Research Uk Centre For Cancer Therapeutics

LigandPNGBDBM25589(7-({6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}...)
Affinity DataIC50: 4.40E+4nMAssay Description:BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2008
Entry Details Article
PubMed