BDBM255515 US10828301, Compound R950368::US9499493, R950368

SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OCCC(N)c4c3)n2)c1

InChI Key InChIKey=BONRMPSOCBJJJO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255515   

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM255515(US9499493, R950368 | US10828301, Compound R950368)
Affinity DataIC50: 10.7nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM255515(US9499493, R950368 | US10828301, Compound R950368)
Affinity DataIC50: 10.7nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent