BDBM255488 US10828301, Compound R935191::US9499493, R935191

SMILES Oc1cccc(Nc2nc(Nc3ccc4cn[nH]c4c3)ncc2F)c1

InChI Key InChIKey=MBZMMQNDGGKJTG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 255488   

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM255488(US9499493, R935191 | US10828301, Compound R935191)
Affinity DataIC50: 45nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase SYK(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM255488(US9499493, R935191 | US10828301, Compound R935191)
Affinity DataIC50: 45nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
Go to US Patent