BDBM254918 US9499542, 1::US9675594, 1

SMILES COc1cccc(c1)-c1ccnc2[nH]cc(C#N)c12

InChI Key InChIKey=ZZDGQQQSEKEUFO-UHFFFAOYSA-N

Data  2 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 254918   

LigandPNGBDBM254918(US9675594, 1 | US9499542, 1)
Affinity DataIC50: 201nMpH: 8.5 T: 2°CAssay Description:LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

LigandPNGBDBM254918(US9675594, 1 | US9499542, 1)
Affinity DataIC50: 247nMpH: 8.5 T: 2°CAssay Description:LRRK2 kinase activity is measured using a LanthaScreen kinase activity assay available from Invitrogen (Life Technologies Corporation). The assay is ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

LigandPNGBDBM254918(US9675594, 1 | US9499542, 1)
Affinity DataEC50:  201nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

LigandPNGBDBM254918(US9675594, 1 | US9499542, 1)
Affinity DataEC50:  247nMAssay Description:In the assay, 1 nM LRRK2 WT or 250 pM LRRK2 G2019S kinase is incubated with the test compound (typically at 0 to 30 μM) for 30 minutes before th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

LigandPNGBDBM254918(US9675594, 1 | US9499542, 1)
Affinity DataIC50: 247nMAssay Description:Inhibition of wild type recombinant human GST-tagged LRRK2 (970 to 2527 residues) expressed in baculovirus using fluorescein-LRRKtide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
LigandPNGBDBM254918(US9675594, 1 | US9499542, 1)
Affinity DataIC50: 354nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 G2019S mutant (970 to 2527 residues) expressed in baculovirus using fluorescein-LRRKtide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
LigandPNGBDBM254918(US9675594, 1 | US9499542, 1)
Affinity DataKi:  6nMAssay Description:Inhibition of human wild type LRRK2 phosphorylation at ser935 transfected in HEK293 cells after 48 hrs by in-cell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed
LigandPNGBDBM254918(US9675594, 1 | US9499542, 1)
Affinity DataKi:  6nMAssay Description:Inhibition of wild type recombinant human GST-tagged LRRK2 (970 to 2527 residues) expressed in baculovirus using fluorescein-LRRKtide as substrate af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/23/2019
Entry Details Article
PubMed