BDBM254380 US10112937, Example 287::US10150765, Example 287::US10703749, Example 287::US9464084, 287

SMILES C[C@H]1Cc2c(nnn2-c2ccccc2)[C@@H](C)N1C(=O)c1cccc(c1Cl)C(F)(F)F

InChI Key InChIKey=INFKYEYKQNYCAE-UHFFFAOYSA-N

Data  5 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 254380   

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 2.80nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at recombinant rat P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at recombinant human P2X7 receptor expressed in 1321N1 cells measured after 30 mins by fluorescence based calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 2.80nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 7nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 2.80nMAssay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 7nMAssay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 7nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 2.80nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 7nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 2.80nMpH: 7.4Assay Description:1321 N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataIC50: 7nMpH: 7.4Assay Description:1321 N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataKi:  14.1nMAssay Description:human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataKi:  14.1nMAssay Description:Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataKi:  14.1nMAssay Description:uman or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataKi:  14.1nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM254380(US9464084, 287 | US10112937, Example 287 | US10150...)
Affinity DataKi:  14.1nMAssay Description:uman or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent