BDBM254233 US10112937, Example 118::US10150765, Example 118::US10703749, Example 118::US9464084, 118

SMILES C[C@H]1Cc2c(CN1C(=O)c1cccc(c1Cl)C(F)(F)F)nnn2-c1ccccn1

InChI Key InChIKey=SISYDQNAILIMSB-UHFFFAOYSA-N

Data  5 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 254233   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.19E+3nMpH: 7.4Assay Description:1321 N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.74E+3nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.19E+3nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide or diclofenac as substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2019
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.74E+3nMAssay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.19E+3nMAssay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.74E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.19E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.74E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.19E+3nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataIC50: 1.74E+3nMpH: 7.4Assay Description:1321 N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataKi:  794nMAssay Description:Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataKi:  794nMAssay Description:uman or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataKi:  794nMAssay Description:uman or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataKi:  794nMAssay Description:Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2021
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM254233(US9464084, 118 | US10112937, Example 118 | US10150...)
Affinity DataKi:  794nMAssay Description:human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2017
Entry Details
Go to US Patent