BDBM254016 US9701685, 26::chiral ethyl-4-[[(2'R,3'R,3'S,5'S)-6-chloro-3'(3-chloro-2-fluoro-phenyl)-2-oxo-5'-[(2R)-3,3,3-trifluoro-2-methyl-propyl]spiro[indoline-2,4'-pyrrolidine]-2'-carbonyl]amino]-3-methoxy-benzoate

SMILES CCOC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](C[C@@H](C)C(F)(F)F)[C@]3(C2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc32)c(OC)c1

InChI Key InChIKey=KBLDTSBKELBYLQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 254016   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Hudson Biopharma

US Patent
LigandPNGBDBM254016(chiral ethyl-4-[[(2'R,3'R,3'S,5'S)-6-chloro-3'(3-c...)
Affinity DataIC50: 7.20nMpH: 7.4 T: 2°CAssay Description:Test compounds (12.34 uM stock in DMSO) were diluted three fold in series in DMSO and 2 ul per well were added into 384-well polypropylene plates (Ma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent