BDBM254014 US9701685, 21::chiral 4-[(2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2-fluoro-phenyl)-5'-(3-fluoro-2,2-dimethyl-propyl)-2-oxo-spiro[indoline-3,4'-pyrrolidine]-2'-carbonyl]amino-3-methoxy-benzoic acid

SMILES COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)CF)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(O)=O

InChI Key InChIKey=PKUBNXZBVDLSFQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 254014   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Hudson Biopharma

US Patent
LigandPNGBDBM254014(chiral 4-[(2'R,3R,3'S,5'S)-6-chloro-3'-(3-chloro-2...)
Affinity DataIC50: 3.60nMpH: 7.4 T: 2°CAssay Description:Test compounds (12.34 uM stock in DMSO) were diluted three fold in series in DMSO and 2 ul per well were added into 384-well polypropylene plates (Ma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent