BDBM254008 US9701685, 10::US9701685, 65::racemic 4-[[(2''R,3R,3''S,5''S)-6-chloro-3''-(3-chloro-2-fluoro-phenyl)-2-oxo-5''-[(2S)-3,3,3-trifluoro-2-methyl-propyl]spiro[indoline-3,4''-pyrrolidine]-2''-carbonyl]amino]-3-methoxy-benzoic acid

SMILES COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](C[C@H](C)C(F)(F)F)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(O)=O

InChI Key InChIKey=XYTHOOGTVUYJBG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 254008   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Hudson Biopharma

US Patent
LigandPNGBDBM254008(US9701685, 10 | racemic 4-[[(2''R,3R,3''S,5''S)-6-...)
Affinity DataIC50: 7.20nMpH: 7.4 T: 2°CAssay Description:Test compounds (12.34 uM stock in DMSO) were diluted three fold in series in DMSO and 2 ul per well were added into 384-well polypropylene plates (Ma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Hudson Biopharma

US Patent
LigandPNGBDBM254008(US9701685, 10 | racemic 4-[[(2''R,3R,3''S,5''S)-6-...)
Affinity DataIC50: 3.60nMpH: 7.4 T: 2°CAssay Description:Test compounds (12.34 uM stock in DMSO) were diluted three fold in series in DMSO and 2 ul per well were added into 384-well polypropylene plates (Ma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent