BDBM25298 (1-hydroxy-1-phosphonoheptyl)phosphonic acid::CHEMBL55264::bisphosphonate, 10

SMILES CCCCCCC(O)(P(=O)(O)O)P(=O)(O)O

InChI Key InChIKey=IJEGNOYPWRBKAE-UHFFFAOYSA-N

Data  4 KI  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 25298   

TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataIC50: 1.12E+4nMAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataIC50: 2.37E+3nMAssay Description:Inhibition of Trypanosoma cruzi farnesyl pyrophosphate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyprenyl synthetase family protein(Leishmania donovani)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataIC50: 5.88E+3nMAssay Description:Inhibitory activity against Leishmania major Farnesyl diphosphate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataIC50: 1.94E+3nMAssay Description:Inhibitory concentration against Trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataIC50: 2.37E+3nMAssay Description:Inhibition of Trypanosoma cruzi farnesyl pyrophosphate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataIC50: 5.89E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME (M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl diphosphate synthase(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataIC50: 1.94E+3nMAssay Description:Inhibition of Trypanosoma cruzi FPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataKi:  240nMAssay Description:Binding affinity towards Trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataKi:  400nMAssay Description:Inhibition of Trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl diphosphate synthase(Trypanosoma cruzi)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataKi:  400nMAssay Description:Inhibition of Trypanosoma cruzi FPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25298(CHEMBL55264 | (1-hydroxy-1-phosphonoheptyl)phospho...)
Affinity DataKi:  560nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed