BDBM25290 CHEMBL56073::bisphosphonate, 39::{1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosphonopropyl}phosphonic acid

SMILES C[N@](CCCCc1ccccc1)CCC(O)(P(=O)(O)O)P(=O)(O)O

InChI Key InChIKey=VFLFYDXGZMGUAF-UHFFFAOYSA-N

Data  1 KI  7 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 25290   

TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25290({1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosph...)
Affinity DataIC50: 4.17E+3nMAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25290({1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosph...)
Affinity DataIC50: 490nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyprenyl synthetase family protein(Leishmania donovani)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25290({1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosph...)
Affinity DataIC50: 490nMAssay Description:Inhibitory activity against Leishmania major Farnesyl diphosphate synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25290({1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosph...)
Affinity DataIC50: 1nMAssay Description:Negative logarithm of inhibitory concentration against bone resorptionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25290({1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosph...)
Affinity DataIC50: 490nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME (M)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetFarnesyl diphosphate synthase(Escherichia coli (strain K12))
University of Illinois At Urbana - Champaign

Curated by ChEMBL
LigandPNGBDBM25290({1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosph...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Escherichia coli FPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Escherichia coli (strain K12))
University of Illinois At Urbana - Champaign

Curated by ChEMBL
LigandPNGBDBM25290({1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosph...)
Affinity DataIC50: 2.45E+5nMAssay Description:Inhibition of Escherichia coli DXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetFarnesyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25290({1-hydroxy-3-[methyl(4-phenylbutyl)amino]-1-phosph...)
Affinity DataKi:  46nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed