BDBM25289 bisphosphonate, 38::{1-hydroxy-2-[3-(3-phenylphenyl)phenoxy]-1-phosphonoethyl}phosphonic acid

SMILES OC(COc1cccc(c1)-c1cccc(c1)-c1ccccc1)(P(O)(O)=O)P(O)(O)=O

InChI Key InChIKey=NWIARQRYIRVYCM-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25289   

TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25289({1-hydroxy-2-[3-(3-phenylphenyl)phenoxy]-1-phospho...)
Affinity DataIC50: 4.07E+3nMAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Baker's yeast)
Institute of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25289({1-hydroxy-2-[3-(3-phenylphenyl)phenoxy]-1-phospho...)
Affinity DataIC50: 140nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25289({1-hydroxy-2-[3-(3-phenylphenyl)phenoxy]-1-phospho...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Baker's yeast)
Institute of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25289({1-hydroxy-2-[3-(3-phenylphenyl)phenoxy]-1-phospho...)
Affinity DataKi:  60nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGeranylgeranyl pyrophosphate synthase(Human)
National Taiwan University

LigandPNGBDBM25289({1-hydroxy-2-[3-(3-phenylphenyl)phenoxy]-1-phospho...)
Affinity DataKi:  110nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed