BDBM25229 2,4-Pyrimidine derivative, 31::4-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-2-N-[3-(morpholin-4-yl)phenyl]pyrimidine-2,4-diamine

SMILES c1cc(cc(c1)N2CCOCC2)Nc3nccc(n3)Nc4c(ccc5c4OCO5)Cl

InChI Key InChIKey=PNEWIQAEGKQNCE-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 25229   

TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM25229(4-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-2-N-[3-(mor...)
Affinity DataIC50: 580nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM25229(4-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-2-N-[3-(mor...)
Affinity DataIC50: 580nMAssay Description:Inhibition of EphB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)