BDBM25223 2,4-Pyrimidine derivative, 25::3-({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzene-1-sulfonamide

SMILES c1cc(cc(c1)S(=O)(=O)N)Nc2nccc(n2)Nc3c(ccc4c3OCO4)Cl

InChI Key InChIKey=TZHCXOMEOHEZDX-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25223   

TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM25223(3-({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]pyr...)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM25223(3-({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]pyr...)
Affinity DataIC50: 40nMAssay Description:Inhibition of EphB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 4(Human)
Astrazeneca

LigandPNGBDBM25223(3-({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]pyr...)
Affinity DataIC50: 172nMAssay Description:Inhibition of Myc-His-tagged EphB4 expressed in CHOK1 cells assessed as phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)