BDBM252070 US9458110, 141::US9458110, 142

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)NC(C)c1c(F)cccc1F

InChI Key InChIKey=WSXKSMSBOLIXMK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 252070   

TargetRho-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM252070(US9458110, 142 | US9458110, 141)
Affinity DataIC50: 5.5nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM252070(US9458110, 142 | US9458110, 141)
Affinity DataIC50: 143nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM252070(US9458110, 142 | US9458110, 141)
Affinity DataIC50: 1.01nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM252070(US9458110, 142 | US9458110, 141)
Affinity DataIC50: 43.3nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details
Go to US Patent