BDBM251889 US9475809, 1::US9918969, 1

SMILES Clc1cccc(c1)-c1cc(=O)n(CC(=O)Nc2ccc(cc2)-c2nnn[nH]2)c2CNC(=O)c12

InChI Key InChIKey=BUVUMAPNDQFBAF-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 251889   

TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM251889(US9475809, 1 | US9918969, 1)
Affinity DataIC50: 930nMpH: 7.4 T: 2°CAssay Description:The factor XIa inhibition of the inventive substances is determined using a biochemical test system which utilizes the reaction of a peptidic factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM251889(US9475809, 1 | US9918969, 1)
Affinity DataIC50: 930nMAssay Description:The factor XIa inhibition of the inventive substances is determined using a biochemical test system which utilizes the reaction of a peptidic factor ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
Go to US Patent

LigandPNGBDBM251889(US9475809, 1 | US9918969, 1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human plasma trypsin using Boc-Ile-Glu-Gly-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProthrombin(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM251889(US9475809, 1 | US9918969, 1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human plasma thrombin using Boc-Asp(OBzl)-Pro-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM251889(US9475809, 1 | US9918969, 1)
Affinity DataIC50: 930nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor X(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM251889(US9475809, 1 | US9918969, 1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human plasma FXa using Boc-Ile-Glu-Gly-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM251889(US9475809, 1 | US9918969, 1)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human plasma Kallikrein using H-Pro-Phe-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed