BDBM25158 CHEMBL507716::N-[(1R)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide::thiophene derivative, 3d

SMILES C[C@@H](NC(=O)c1ccc(s1)C(=O)C(F)(F)F)c1ccccc1

InChI Key InChIKey=DPKHRWMGXRDLLO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 25158   

TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25158(N-[(1R)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 320nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2008
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25158(N-[(1R)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 230nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2008
Entry Details Article
PubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25158(N-[(1R)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 160nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2008
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25158(N-[(1R)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 76nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2008
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25158(N-[(1R)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 360nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2008
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25158(N-[(1R)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 76nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25158(N-[(1R)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 230nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25158(N-[(1R)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 320nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25158(N-[(1R)-1-phenylethyl]-5-(2,2,2-trifluoroacetyl)th...)
Affinity DataIC50: 360nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed