BDBM25152 CHEMBL112446::N-methyl-2-oxo-N'-(3-phenylphenyl)nonanediamide::ketoamide, 12

SMILES CNC(=O)C(=O)CCCCCCC(=O)Nc1cccc(c1)-c1ccccc1

InChI Key InChIKey=QUTIXALGBQKSDN-UHFFFAOYSA-N

Data  3 IC50  2 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25152   

TargetHistone deacetylase 1(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25152(N-methyl-2-oxo-N'-(3-phenylphenyl)nonanediamide | ...)
Affinity DataIC50: 12nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25152(N-methyl-2-oxo-N'-(3-phenylphenyl)nonanediamide | ...)
Affinity DataIC50: 10nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25152(N-methyl-2-oxo-N'-(3-phenylphenyl)nonanediamide | ...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Irbm/Merck Research Laboratories

LigandPNGBDBM25152(N-methyl-2-oxo-N'-(3-phenylphenyl)nonanediamide | ...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetHistone deacetylase (HDAC1 and HDAC2)(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM25152(N-methyl-2-oxo-N'-(3-phenylphenyl)nonanediamide | ...)
Affinity DataIC50: 3.70nMAssay Description:Inhibitory activity against mixture of histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2) from nuclear extraction of K562 erythroleukemi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2018
Entry Details Article
PubMed