BDBM251508 US9452998, 57

SMILES CN(C)c1ccc(c(n1)-c1cnc(N)c(n1)C(=O)Nc1ncccc1N1CCC(N)CC1)C(F)(F)F

InChI Key InChIKey=VHOMUDQDZZWLSZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 251508   

TargetProtein kinase C alpha type(Human)
Novartis

US Patent
LigandPNGBDBM251508(US9452998, 57)
Affinity DataIC50: 0.130nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251508(US9452998, 57)
Affinity DataIC50: 0.870nMpH: 7.4Assay Description:The compounds of formula I were tested for their activity on different PKC isoforms according to a published method (D. Geiges et al. Biochem. Pharma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details
Go to US Patent

TargetProtein kinase C alpha type(Human)
Novartis

US Patent
LigandPNGBDBM251508(US9452998, 57)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein kinase C theta type(Human)
Novartis

US Patent
LigandPNGBDBM251508(US9452998, 57)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed