BDBM250376 US10501411, Example 286::US11312711, Example 14::US11697636, Example 286::US9452980, 286

SMILES Cc1cc(cc(Cl)n1)C(=O)Nc1ccc(cc1)[C@H]1CNCCO1

InChI Key InChIKey=UJWNXKANZXVFHO-UHFFFAOYSA-N

Data  8 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 250376   

TargetTrace amine-associated receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataEC50:  447nMAssay Description:For the construction of expression plasmids the coding sequences of human TAAR 1 were amplified from genomic DNA essentially as described by Lindeman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataIC50: 7.32E+4nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of the test items on hERG (human-ether-a-go-go related gene) potassium chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetTrace amine-associated receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataEC50:  447nMAssay Description:For the construction of expression plasmids the coding sequences of human TAAR1 were amplified from genomic DNA essentially as described by Lindemann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataIC50: 7.32E+4nMAssay Description:The whole-cell patch-clamp technique was used to investigate the effects of the test items on hERG (human-ether-a-go-go related gene) potassium chann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent

TargetTrace amine-associated receptor 1(Rat)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataKi:  4.40nM ΔG°:  -11.9kcal/molepH: 7.4 T: 2°CAssay Description:HEK-293 cells stably expressing rat TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetTrace amine-associated receptor 1(Rat)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataKi:  4.40nMAssay Description:The TAAR1 radioligand 3[H] (S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent

TargetTrace amine-associated receptor 1(Rat)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataKi:  4.40nMAssay Description:Rat: The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetTrace amine-associated receptor 1(Mouse)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataKi:  22.2nM ΔG°:  -10.9kcal/molepH: 7.4 T: 2°CAssay Description:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37° C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetTrace amine-associated receptor 1(Mouse)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataKi:  22.2nMAssay Description:The TAAR1 radioligand 3[H] (S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
Go to US Patent

TargetTrace amine-associated receptor 1(Mouse)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataKi:  22.2nMAssay Description:Mouse: The TAAR1 radioligand 3[H]-(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine (described in WO 2008/098857) was used at a concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetSodium-dependent dopamine transporter(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataKi:  7.32E+3nMAssay Description:Binding to dopamine transporter (DAT) in vitro. Human embryonic kidney (HEK) 293 cells (Invitrogen, Zug, Switzerland) stably transfected with human D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
Go to US Patent

TargetSodium-dependent dopamine transporter(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM250376(US9452980, 286 | US10501411, Example 286 | US11312...)
Affinity DataKi:  7.32E+3nMAssay Description:Binding to dopamine transporter (DAT) in vitro. Human embryonic kidney (HEK) 293 cells (Invitrogen, Zug, Switzerland) stably transfected with human D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
Go to US Patent