BDBM250058 US10005782, Compound 183::US9447106, 183::US9556188, Compound 183

SMILES NC(=O)c1c2NCCC(C3CCN(CC3)C(=O)C=C)n2nc1-c1ccc(Oc2ccc(F)cc2F)cc1

InChI Key InChIKey=DFUIAUMNSYRTOL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 250058   

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250058(US9447106, 183 | US9556188, Compound 183 | US10005...)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250058(US9447106, 183 | US9556188, Compound 183 | US10005...)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250058(US9447106, 183 | US9556188, Compound 183 | US10005...)
Affinity DataIC50: 1.20nMAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250058(US9447106, 183 | US9556188, Compound 183 | US10005...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells using Biotin-AVLESEEELYSS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Beigene (Beijing) Co.

Curated by ChEMBL
LigandPNGBDBM250058(US9447106, 183 | US9556188, Compound 183 | US10005...)
Affinity DataIC50: 18nMAssay Description:Inhibition of EGFR (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Beigene (Beijing) Co.

Curated by ChEMBL
LigandPNGBDBM250058(US9447106, 183 | US9556188, Compound 183 | US10005...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of TEC (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed