BDBM250054 US10005782, Compound 176::US9447106, 176::US9556188, Compound 176

SMILES CC#CC(=O)N1CCC(CC1)[C@@H]1CCNc2c(C(N)=O)c(nn12)-c1ccc(Oc2ccccc2)cc1

InChI Key InChIKey=HJAUUHMYFPHMCT-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 250054   

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250054(US9447106, 176 | US9556188, Compound 176 | US10005...)
Affinity DataIC50: 3nMT: 2°CAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250054(US9447106, 176 | US9556188, Compound 176 | US10005...)
Affinity DataIC50: 3nMT: 2°CAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250054(US9447106, 176 | US9556188, Compound 176 | US10005...)
Affinity DataIC50: 3nMAssay Description:Compounds disclosed herein were tested for inhibition of Btk kinase activity in an assay based on time-resolved fluorescence resonance energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250054(US9447106, 176 | US9556188, Compound 176 | US10005...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal His-tagged recombinant human BTK (393 to 659 residues) expressed in baculovirus infected Sf9 cells using Biotin-AVLESEEELYSS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Beigene (Beijing) Co.

Curated by ChEMBL
LigandPNGBDBM250054(US9447106, 176 | US9556188, Compound 176 | US10005...)
Affinity DataIC50: 2.61E+3nMAssay Description:Inhibition of EGFR (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Beigene (Beijing) Co.

Curated by ChEMBL
LigandPNGBDBM250054(US9447106, 176 | US9556188, Compound 176 | US10005...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of TEC (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Beigene

US Patent
LigandPNGBDBM250054(US9447106, 176 | US9556188, Compound 176 | US10005...)
Affinity DataIC50: 15nMAssay Description:Inhibition of BTK phosphorylation at Tyr 223 residue in human Ramos cell incubated for 3 hrs by HTRF-based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase TXK(Human)
Beigene (Beijing) Co.

Curated by ChEMBL
LigandPNGBDBM250054(US9447106, 176 | US9556188, Compound 176 | US10005...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human TXK preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Beigene (Beijing) Co.

Curated by ChEMBL
LigandPNGBDBM250054(US9447106, 176 | US9556188, Compound 176 | US10005...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human BMX preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed