BDBM24989 4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine::oxadiazole-containing compound, 1

SMILES CCn1c(nc2cncc(OC3CCNCC3)c12)-c1nonc1N

InChI Key InChIKey=BGZVXNSBCSLMND-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 24989   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50: 79nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2008
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Glaxosmithkline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50: 1.00E+3nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2008
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Glaxosmithkline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50: 398nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2008
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Glaxosmithkline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50: 21nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2008
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50: 8nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2008
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50: 8nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-5(Human)
Glaxosmithkline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50: 21nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50: 79nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Glaxosmithkline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50: 398nMAssay Description:Inhibition of Akt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Glaxosmithkline

LigandPNGBDBM24989(4-[1-ethyl-7-(piperidin-4-yloxy)-1H-imidazo[4,5-c]...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Akt2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed