BDBM249336 US10300060, Example 15-98::US10765676, Example 15-98::US9463192, 15-98::US9763943, 15-98::US9993479, 15-98

SMILES CS(=O)(=O)c1ccc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cc(cnc2N)C(F)(F)F)nc1)C(F)(F)F

InChI Key InChIKey=QZTGJELMWQYJCV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249336   

TargetHigh affinity nerve growth factor receptor(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM249336(US9463192, 15-98 | US9763943, 15-98 | US9993479, 1...)
Affinity DataIC50: 0.800nMT: 2°CAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM249336(US9463192, 15-98 | US9763943, 15-98 | US9993479, 1...)
Affinity DataIC50: 0.800nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2019
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM249336(US9463192, 15-98 | US9763943, 15-98 | US9993479, 1...)
Affinity DataIC50: 0.800nMAssay Description:TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM249336(US9463192, 15-98 | US9763943, 15-98 | US9993479, 1...)
Affinity DataIC50: 0.800nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM249336(US9463192, 15-98 | US9763943, 15-98 | US9993479, 1...)
Affinity DataIC50: 0.800nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent