BDBM249054 US9434725, 285

SMILES CCNc1cncc(n1)-c1cc2n(ncc2cn1)-c1cccc(n1)N1CCNCC1

InChI Key InChIKey=XXIAOEADCPRWAT-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 249054   

TargetSerine/threonine-protein kinase pim-1(Mouse)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249054(US9434725, 285)
Affinity DataIC50: 112nMAssay Description:BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249054(US9434725, 285)
Affinity DataKi:  0.0440nM ΔG°:  -14.1kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249054(US9434725, 285)
Affinity DataKi:  0.0900nM ΔG°:  -13.7kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM249054(US9434725, 285)
Affinity DataKi:  2.28nM ΔG°:  -11.8kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
Go to US Patent