BDBM248583 US9434711, 496
SMILES Cc1c(sc2ccccc12)N(Cc1ccc(OC(F)(F)F)cc1)S(=O)(=O)c1ccc(cc1)C(O)=O
InChI Key InChIKey=AZOVCAUOKWYQTD-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 248583
Affinity DataIC50: 0.800nMT: 2°CAssay Description:The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rat)
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.80nMT: 2°CAssay Description:For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Human)
Janssen Pharmaceutica
US Patent
Janssen Pharmaceutica
US Patent
Affinity DataIC50: 1.40nMT: 2°CAssay Description:For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex...More data for this Ligand-Target Pair
Affinity DataIC50: 0.183nMAssay Description:For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100...More data for this Ligand-Target Pair
Affinity DataIC50: 0.554nMAssay Description:For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100...More data for this Ligand-Target Pair